Open Access Open Access  Restricted Access Subscription or Fee Access

Cluster Analysis of MR Imaging in Alzheimer’s Disease using Decision Tree Refinement

Ali Hamou, Andrew Simmons, Michael Bauer, Benoit Lewden, Yi Zhang, Lars-Olof Wahlund, Eric Westman, Megan Pritchard, Iwona Kloszewska, Patrizia Mecozzi, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Sebastian Muehlboeck, Alan Evans, Per Julin, Niclas Sjögren, Christian Spenger, Simon Lovestone, Femida Gwadry-Sridhar


The use of novel analytical techniques (such as data clustering and decision trees) that can model and predict patient disease outcomes has great potential for assessing disease process and progression in Alzheimer’s disease and mild cognitive impairment. For this study, 124 different variables (generated from image data, demographics and data) have been compiled and analyzed using a modified clustering algorithm. Our aim was to determine the influence of these variables on the incidence of Alzheimer’s and mild cognitive impairment. Furthermore, we used a decision tree algorithm to model the level of “importance” of variants influencing this decision.


Alzheimer's Disease, Mild Cognitive Impairment, Cluster Analysis, Decision Tree Analysis, MRI

Full Text:



  • There are currently no refbacks.

Disclaimer/Regarding indexing issue:

We have provided the online access of all issues and papers to the indexing agencies (as given on journal web site). It’s depend on indexing agencies when, how and what manner they can index or not. Hence, we like to inform that on the basis of earlier indexing, we can’t predict the today or future indexing policy of third party (i.e. indexing agencies) as they have right to discontinue any journal at any time without prior information to the journal. So, please neither sends any question nor expects any answer from us on the behalf of third party i.e. indexing agencies.Hence, we will not issue any certificate or letter for indexing issue. Our role is just to provide the online access to them. So we do properly this and one can visit indexing agencies website to get the authentic information.